Diverse Immune Responses to Orally Administered Heat-Killed Cell Preparation of Enterococcus faecalis Strain EC-12 in Murine Immune Tissues

Tohru YOSHIKAWA; Ryo INOUE; Yoko YOSHIDA; Takumi WATANABE; Wakoto BUKAWA; Kazunari USHIDA

doi:10.1271/bbb.90010

This article has now been updated. Please use the final version.

Diverse Immune Responses to Orally Administered Heat-Killed Cell Preparation of Enterococcus faecalis Strain EC-12 in Murine Immune Tissues

Tohru YOSHIKAWA, Ryo INOUE, Yoko YOSHIDA, Takumi WATANABE, Wakoto BUKAWA, Kazunari USHIDA

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Keywords: heat-killed bacteria, Peyer’s patch, cytokine, chemokine

JOURNAL FREE ACCESS Advance online publication

Article ID: 90010

DOI https://doi.org/10.1271/bbb.90010

The final version of this article is now available: Vol. 73 (2009) , No. 6 p.1439

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Abstract

Diverse immune responses to an orally administered heat-killed cell preparation of Enterococcus faecalis strain EC-12 (EC-12) among jejunal-Peyer’s patches (PPs), ileal-PPs, mesenteric lymph nodes (MLNs), and spleen were compared by real-time PCR in mice. Intriguingly, distinct responses to EC-12 were observed in the various tissues. This study indicates a site-specific response to orally administered bacteria, particularly in jejunal- and ileal-PPs.

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