Syntheses and Antimicrobial Activity of Tetrasubstituted Tetrahydrofuran Lignan Stereoisomers

Tomofumi NAKATO; Satoshi YAMAUCHI; Ryosuke TAGO; Koichi AKIYAMA; Masafumi MARUYAMA; Takuya SUGAHARA; Taro KISHIDA; Yojiro KOBA

doi:10.1271/bbb.90107

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Syntheses and Antimicrobial Activity of Tetrasubstituted Tetrahydrofuran Lignan Stereoisomers

Tomofumi NAKATO, Satoshi YAMAUCHI, Ryosuke TAGO, Koichi AKIYAMA, Masafumi MARUYAMA, Takuya SUGAHARA, Taro KISHIDA, Yojiro KOBA

著者情報

キーワード: lignan, tetrahydrofuran lignan, antimicrobial activity

ジャーナルフリー早期公開

論文ID: 90107

DOI https://doi.org/10.1271/bbb.90107

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 7 p.1608

詳細

抄録

The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9,9′-diol compound bearing (7R,7′R,8R,8′R) and (7R,7′S,8R,8′R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that (−)-virgatusin bearing (7S,7′R,8S,8′S) stereochemistry had strongest antifungal activity.

責任著者(Corresponding author)

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