Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation

Masashi MIZUNO; Yosuke NISHITANI; Takashi HASHIMOTO; Kazuki KANAZAWA

doi:10.1271/bbb.90326

This article has now been updated. Please use the final version.

Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation

Masashi MIZUNO, Yosuke NISHITANI, Takashi HASHIMOTO, Kazuki KANAZAWA

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Keywords: fucoidan, lentinan, interleukin-8, tumor necrosis factor-α, intestinal bowel diseases

JOURNAL FREE ACCESS Advance online publication

Article ID: 90326

DOI https://doi.org/10.1271/bbb.90326

The final version of this article is now available: Vol. 73 (2009) , No. 10 p.2324

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Abstract

A system for assessing the anti-inflammatory effects of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells and macrophage RAW264.7 cells. The results indicate that fucoidan and lentinan exhibited different suppressive effects on interleukin-8 (IL-8) mRNA expression in Caco-2 through tumor necrosis factor-α (TNF-α) production from RAW264.7 stimulated with lipopolysaccharide (LPS).

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