Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature

Mamiko ASANO; Kazuo HARADA; Tomoaki YOSHIKAWA; Takeshi BAMBA; Kazumasa HIRATA

doi:10.1271/bbb.90545

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature

Mamiko ASANO, Kazuo HARADA, Tomoaki YOSHIKAWA, Takeshi BAMBA, Kazumasa HIRATA

著者情報

キーワード: FMN, near-ultraviolet light (NUV), Catharanthus roseus, dimeric indole alkaloids (DIAs)

ジャーナルフリー早期公開

論文ID: 90545

DOI https://doi.org/10.1271/bbb.90545

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.386

詳細

抄録

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）