Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

Issei DAIRAKU; Yunkyung HAN; Noriyuki YANAKA; Norihisa KATO

doi:10.1271/bbb.90568

This article has now been updated. Please use the final version.

Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

Issei DAIRAKU, Yunkyung HAN, Noriyuki YANAKA, Norihisa KATO

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Keywords: IMP dehydrogenase, polyphenol, curcumin, anticancer agent, antiviral agent

JOURNAL FREE ACCESS Advance online publication

Article ID: 90568

DOI https://doi.org/10.1271/bbb.90568

The final version of this article is now available: Vol. 74 (2010) , No. 1 p.185

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Abstract

Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.

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