Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

Issei DAIRAKU; Yunkyung HAN; Noriyuki YANAKA; Norihisa KATO

doi:10.1271/bbb.90568

Food & Nutrition Science Notes

Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents

Issei DAIRAKU, Yunkyung HAN, Noriyuki YANAKA, Norihisa KATO

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Keywords: IMP dehydrogenase, polyphenol, curcumin, anticancer agent, antiviral agent

JOURNAL FREE ACCESS

2010 Volume 74 Issue 1 Pages 185-187

DOI https://doi.org/10.1271/bbb.90568

View "Advance Publication" version (January 7, 2010).

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Abstract

Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.

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