Matriptase Does Not Require Hepatocyte Growth Factor Activator Inhibitor Type-1 for Activation in an Epithelial Cell Expression Model

Yuka MIYAKE; Satoshi TSUZUKI; Tohru FUSHIKI; Kuniyo INOUYE

doi:10.1271/bbb.90696

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Matriptase Does Not Require Hepatocyte Growth Factor Activator Inhibitor Type-1 for Activation in an Epithelial Cell Expression Model

Yuka MIYAKE, Satoshi TSUZUKI, Tohru FUSHIKI, Kuniyo INOUYE

著者情報

キーワード: activation of matriptase, C-terminal fragments, hepatocyte growth factor activator inhibitor type-1, Madin–Darby canine kidney cells, simple epithelial cells

ジャーナルフリー早期公開

論文ID: 90696

DOI https://doi.org/10.1271/bbb.90696

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 4 p.848

詳細

抄録

Matriptase is a type II transmembrane serine protease. Paradoxically, activation of this protease is thought to require its physiological inhibitor, hepatocyte growth factor activator inhibitor type-1 (HAI-1). In the present study, however, we obtained evidence in a stable transfection experiment using Madin–Darby canine kidney cells that matriptase activation does not require HAI-1.

責任著者(Corresponding author)

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