Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

Yoko ISHIMOTO; Yuji NAKAI; Hideo SATSU; Mamoru TOTSUKA; Makoto SHIMIZU

doi:10.1271/bbb.90732

This article has now been updated. Please use the final version.

Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

Yoko ISHIMOTO, Yuji NAKAI, Hideo SATSU, Mamoru TOTSUKA, Makoto SHIMIZU

Author information

Keywords: coculture, IEX-1, maSigPro, microarray

JOURNAL FREE ACCESS Advance online publication

Article ID: 90732

DOI https://doi.org/10.1271/bbb.90732

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.437

Details

Abstract

We analyzed changes in gene expression in Caco-2 cells cocultured with THP-1 cells over time periods of 0, 1, 3, 6, 24, and 48 h using a DNA microarray. Differentially expressed genes extracted with maSigPro indicated that an early defense response and cell death occured at the same time, causing an inflammatory condition.

Corresponding author

Register with J-STAGE for free!