Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA; Yutaka HIROSE; Nobutaka FUNA; Yasuo OHNISHI; Sueharu HORINOUCHI

doi:10.1271/bbb.90866

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Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA, Yutaka HIROSE, Nobutaka FUNA, Yasuo OHNISHI, Sueharu HORINOUCHI

著者情報

キーワード: curcuminoid, curcumin, polyketide synthase, precursor-directed biosynthesis, microbial production

ジャーナルフリー早期公開

論文ID: 90866

DOI https://doi.org/10.1271/bbb.90866

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 3 p.641

詳細

抄録

Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.

責任著者(Corresponding author)

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