1. It is confirmed that both linoleic acid and linolenic acid are equally effective in curing a specific deficiency disease produced by rigidly fat-free diets. 2. Oleic acid and elaidic acid induce growth response of rats, but seem to be ineffective in curing sick rats. 3. The rats receiving clupanodonic acid suddenly lose body weight and are not cured with either linoleic acid or linolenic acid. 4. The poor results obtained with stearic acid may be attributed to im-perfect absorption. 5. Vitamin B and G are definitely ruled out as a limiting factor in this dietary deficiency. The author wishes to express her deep gratitude to Professor U. Suzuki for his many helpful suggestions throughout this work and to Dr. W. Nakahara for his invaluable advice on the anatomical examination. She is also indebted to the Keimei Society for financial assistance.
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