Studies on the Corrinoids and Porphyrins in Streptomycetes

Part II. Factors Influencing the Accumulation of Coproporphyrin III in the Culture Filtrate of Streptomyces olivaceus 605

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In a medium containing glycerol as u carbon source, Streptomyces olivaceus 605 accumulated under mild aeration a large amount of porphyrin in the culture filtrate. Identity of methyl ester of the porphrin with coproporphyrin III methyl ester was confirmed by UV-, IR- and NMR- spectroscopy. Under the cultural conditions favarable for production of corrinoid, the accumulation of coproporphyrin III markedly decreased.