Metabolism of Pyridine Coenzymes in Microorganisms

Part IV Reaction of the NADP Analog and NAD Diphosphate with Dehydrogenases

Abstract

The NADP analog and NAD diphosphate were tested for the coenzyme or inhibiting activity toward various dehydrogenases. These NAD derivatives showed little or no ac-tivity of as coenzymes for most of dehydrogenases tested. Only glyceraldehyde 3-phosphate dehydrogenase reduced the NADP analog under the high concentration of enzyme system. These NAD derivatives showed no inhibiting effect toward the reduction or oxidation of pyridine coenzymes.