Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Biochemical Studies on Fatty Liver
Part V. On the Mechanism of Induction of Fatty Liver by Amino Acid Imbalance
Masaji OGURA, Hideyuki TANAKA, Hisayoshi HONDA
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1971 Volume 35 Issue 3 Pages 370-376

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Abstract
Lipid analyses in the fatty liver of rats, which was induced by feeding an amino acid-imbalanced diet containing 8% casein supplemented with 0.3% DL-methionine, were per-formed. In this type of fatty liver, triglycerides were found to be remarkably increased, in comparison with cholesteryl esters, cholesterols, non-esterified fatty acids, phospholipids and glycolipids. In the fatty acid composition of each lipid, no significant difference for the imbalance group was observed, except for that of triglycerides.
It is suggested from the results of treatment with Triton WR-1339 that the transport of triglyceride from the liver to the plasma is not inhibited at all in the imbalance group, and from the determination of fatty acid distribution after feeding a dietary coconut oil that the transport of triglyceride from the adipose tissue to the liver is not almost altered.
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