Abstract
The effects of cyclic adenosine 3', 5'-monophosphate (c-AMP) on carbohydrate metabolism, especially gluconeogenesis, glycolysis, glycogenesis, and glycogenolysis in rats fed a stock diet (commercial pellets) were investigated. Increases in blood glucose levels in rats injected with two different doses of c-AMP intraperitoneally were observed. The rates of increase in blood glucose levels of rats administered 20mg of c-AMP per 100g of body weight were higher than those of rats administered 2mg of c-AMP per 100g of body weight. In vivo gluconeogenic capacity was increased by the injection of either dose of c-AMP. In vivo glucose oxidation was depressed and liver glycogen levels were decreased in rats administered 20mg of c-AMP per 100g of body weight but these changes were not recognized in rats administered 2mg of c-AMP per 100g of body weight. Renal gluconeogenesis was merely stimulated by the injection of the lower dose of c-AMP. Glucose formation from FDP and/or FDP in both liver and kidney cortex homogenates of rats was not stimulated by the injection of c-AMP.
