Constitutional Amino Acids of the Antibiotic YA-56

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Acid hydrolysis of the antibiotic YA-56 X (Zorbamycin) and Y belonging to the phleomycin-bleomycin group was carried out and the following constitutional amino acids were isolated from the hydrolyzate of YA-56 X: β-Amino-β-(4-amino-6-carboxy-5-methylpyrimidine-2-yl)-propionic acid, β-aminoalanine, L-erythro-β-hydroxyhistidine and 3 unidentified amino acids. Though the former 3 amino acids were known to be constituents of phleomycins and bleomycins, the latter three were not found in phleomycins and bleomycins. YA-56 Y gave one more unidentified amino acid.
Furthermore, isolation of β-alanine and 2-acetylthiazole-4-carboxylic acid from the hydrolyzate indicated the presence of 2-(2-(2-aminoethyl)-Δ²-thiazoline-4-yl)-thiazole-4-carboxylic acid in YA-56 X and Y as in phleomycins.