Syntheses of Some Derivatives of Glycosyl Pantothenic Acids, Analogues of Growth Factor for MLF Bacteria

Abstract

A growth factor (TJF) for a malo-lactic fermentation bacterium (Lenconostoc sp.) has been found to be 4'-O-(β-D-glucopyranosyl)-D-pantothenic acid with structural and synthetical studies. Now other 4'-O-glycosides (β-D-ribofuranosyl, α-D-glucopyranosyl, β-D-galactopyranosyl, β-maltosyl and β-cellobiosyl) and 2', 4'-O-di-β-D-glucopyranoside of DL-pantothenic acid, and 4'-O-β-D-glucopyranoside of DL-pantethine were synthesized to examine their biological activities. The improved syntheses of TJF were also examined.