A New Process for the Production of Coenzyme A

Abstract

A new process has been described for the preparation of coenzyme A of high purity from the cultured broth of Brevibacterium mnmoniagenes IFO 12071. The product was obtained in a high yield by the use of Duolite S-30, charcoal, and Dowex 1×2, and identified chemically and enzymatically. This method is simple, rapid, and compact, requires no special equipment, and has been shown to be adaptable for preparing large amounts of highly pure coenzyme A.