Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Accumulation of 6-Azauridine by Mutants of Brevibacterium ammoniagenes
Akira FURUYAFumio KATOKiyoshi NAKAYAMA
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1975 年 39 巻 4 号 p. 767-771

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From the inosine producing mutants of Brevibacterium ammoniagenes, KY 13761 was selected as a strain which produced 6-azauridine from 6-azauracil.
The conditions for the conversion were examined and the intermitent feeding of 6-azauracil was found effective for the accumulation.
In order to increase the accumulation, prototrophic revertants were induced from KY 13761 and KY 13021 was selected. By intermitent feeding of 6-azauracil of a final concentration of 6mg per ml, a maximal accumulation, 12.4mg/ml, of 6-azauridine was obtained with KY 13021.
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