Absorption Efficiency and Biological Half-Life of Individual Chlorobiphenyls in Rats Treated with Kanechlor Products

Abstract

The absorption efficiency and biological half-life of individual chlorobiphenyls (PCBs) contained in Kanechlor products were determined in rats. The absorption efficiencies of PCBs decreased as the number of chlorine atoms substituted in biphenyls increased. It is suspected that the absorption modes of PCBs depended mainly on molecular size. The patterns of PCB decrease after oral administration were roughly classified into the monophasic, biphasic and non-decrease types. It was apparent that PCBs with shorter biological half-lives had a P area which showed both meta and para positions unsubstituted with chlorine atoms in biphenyl ring.