抄録
A study was made of rats fed a high fructose diet to determine whether males and females responded differently to lipoprotein lipase activity and how this response was affected by sex. The rats were meal-fed with a high fructose or a high glucose diet for two weeks. After two days of starvation, each diet-group was divided into three subgroups: (a) fasted, (b) injected with physiological saline solution, and (c) injected with mannoheptulose solution. Subgroups (b) and (c) were then immediately refed their respective meals of the high fructose or the high glucose diet for three hours and then sacrificed. The weights of the liver and adipose tissues, amounts of liver lipids, lipoprotein lipase activities in the adipose tissues and serum immunoreactive insulin concentrations were determined. Males fed the high fructose diet had a significantly higher hepatic lipid content than those fed the high glucose diet. The weight of adipose tissues of females fed the high fructose diet was less than that of those fed the high glucose diet (p<0.01). In males fed the high fructose diet, lipoprotein lipase activity, expressed in units per lOOg body weight per hour, was less than that of males fed the high glucose diet; the females showed a similar trend. Moreover, females on the fructose diet had lower lipoprotein lipase activity than males in same subgroups. The serum immunoreactive insulin level increased in rats fed the high glucose diet after the three hours refeeding, but the serum immunoreactive insulin level of the rats fed the high fructose diet showed a lower elevation.
