Amylase Inhibitors Produced by Streptomyces sp. No. 280

Abstract

Fourteen kinds of amylase inhibitor (AI) were obtained by active carbon column chromatography and other procedures. The molecular weights of the AIs were estimated to be 310-1300 by gel filtration. They seem to have 1-4 glucose residues and one nitrogen per molecule. All the AIs have almost the same inhibitory activity against glucoamylase. High molecular weight AIs have much stronger activity toward α-amylase and phosphorylase α than low molecular weight AIs, but the latter have much stronger inhibitory activity toward sucrase and α-glucosidase than the former. Four kinds of AI were hydrolyzed by β-amylase which changed their inhibitory activities.