Structure-activity Relationship of Herbicidal 2, 3-Dicyano-5-Substituted Pyrazines

Abstract

Sixty six 2, 3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity. The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.