Local Anaesthetic Activity and Synthesis of 2-(N-Substituted or N, N-Disubstituted aminoacetamido)-4-aryl Thiazoles

Abstract

Some new 2-(N-substituted or N, N-disubstituted aminoacetamido)-4-p-nitrophenyl, 4-m-nitrophenyl and 4-(2', 5'-dimethoxy)phenyl thiazoles were synthesised. Their hydrochlorides were screened for local anaesthetic activity by Frog's sciatic plexus method and this activity compared with that of procaine hydrochloride. Among them, the 2-(N-substituted aminoacetamido)-4-m-nitrophenylthiazole hydrochlorides are the most potent: almost twice in terms of the onset of anaesthesia in comparison with procaine-HCl.