Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1
1985 年 49 巻 7 号 p. 1959-1963
詳細
1985 年 49 巻 7 号 p. 1959-1963
A new differentiation screening system employing a human neuroblastoma cell line. NB-1, was used to isolate staurosporine as an inducer obtained from the culture broth of Streptomyces actuosus. Staurosporine at a concentration of 20 nM induced elongation of neurites and cell enlargement one hour after treatment of NB-1. In addition, the agent had a cytotoxic effect against NB-1 at a concentration of more than 0.21 μM.
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