1985 年 49 巻 7 号 p. 1951-1958
Cosmomycins A, B, C and D, new differentiation inducers of Friend cell F5-5, accumulated in the mycelium and culture fluid of a new strain, Streptomyces cosmosus nov. sp. Cosmomycin A and cosmomycin B contain a rhodinosyl-rhodinosyl-rhodosaminyl and rhodinosyl-2-deoxy-L-fucosylrhodosaminyl group at C-10 of γ-rhodomycinone, respectively. Cosmomycins C and D respectively possess the same sugar chains as Cosmomycins A and B at C-10 and the common rhodinosyl-2-deoxy-L-fucosyl-rhodosaminyl group at C-7 of β-rhodomycinone. Cosmomycin D is a new anthracycline compound and cosmomycin A is a new anthracycline compound of microbial origin, but Cosmomycins B and C seem to be identical to γ-rhodomycin Y and β-rhodomycin S-2, respectively. Approximately 20.0%, 15.4%, 16.4% and 14.2% of the F5-5 cells were induced to respectively biosynthesize hemoglobin by 1.25 μg/ml of cosmomycin A, 1.25 μg/ml of cosmomycin B, 7.81ng/ml of cosmomycin C and 15.6ng/ml of cosmomycin D. Other anthracyclines such as aclacinomycin A1, adriamycin and daunomycin had no effect on differentiation.
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