Synthesis and Immunoadjuvant Activity of the Conjugates of 1-Thio-N-acetyl-muramoyl Dipeptide with Lipid A Subunit Analogs

Yuji OGAWA; Masayuki KITAGAWA; Yushun FUJISHIMA; Makoto Kiso; Akira HASEGAWA; Hideharu ISHIDA; Ichiro AZUMA

doi:10.1271/bbb1961.53.1025

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Synthesis and Immunoadjuvant Activity of the Conjugates of 1-Thio-N-acetyl-muramoyl Dipeptide with Lipid A Subunit Analogs

Yuji OGAWA, Masayuki KITAGAWA, Yushun FUJISHIMA, Makoto Kiso, Akira HASEGAWA, Hideharu ISHIDA, Ichiro AZUMA

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JOURNAL FREE ACCESS

1989 Volume 53 Issue 4 Pages 1025-1036

DOI https://doi.org/10.1271/bbb1961.53.1025

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Abstract

A variety of immunomodulators were synthesized by combining biologically active derivatives of 1-thio-muramoyl dipeptide with 4-O-phosphono-D-glucosamine derivatives related to bacterial lipid A, and using the (succinoylamino)undecanoyl group as a spacer. Their immunoadjuvant activities in guinea-pigs were examined.

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