Biosynthetic Study of Chloromonilicin, a Growth Self-inhibitor Having a Novel Lactone Ring, from Monilinia fructicola

Abstract

The biosynthetic route for chloromonilicin, an antifungal substance from cherry rot fungus, was investigated using deuterium-labeled precursors. The incorporation of synthetic deuterium-labeled moniliphenone into chloromonilicin and into its xanthone precursor, 4-chIoropinselin, was confirmed by ¹H-NMR spectrometry.