Pungent Alkamides from Spilanthes acmella L. var. oleracea Clarke

Abstract

A main pungent amide, spilanthol (1), and three alkamides, (2E)-N-(2-methylbutyl)-2-undecene-8, 10-diynamide (2), (2E, 7Z)-N-isobutyl-2, 7-tridecadiene-10, 12-diynamide (3), and (7Z)-N-isobutyl-7-tridecene-10, 12-diynamide (4) were isolated from the flower heads of Spilanthes acmella L. var. oleracea Clarke. Their structures were established by spectroscopic methods. Compounds 2 and 4 were new and 3 was found for the first time in Spilanthes species. Chemotaxonomic aspects are discussed.