Distinct Interaction of TmrB Protein with Membranes in Bacillus subtilis and Escherichia coli

Abstract

TmrB protein, which endows Bacillus subtilis with tunicamycin resistance, was found to bind more tightly to the membrane in B. subtilis than in E. coli. Although only the C-terminal amphiphilic α-helix was responsible for membrane-TmrB interaction in E. coli, there should be other binding factor(s) in the original strain, B. subtilis.