Sweetness of Glycyrrhetic Acid 3-O-β-D-Monoglucuronide and the Related Glycosides

Abstract

Research Laboratories, Maruzen Pharmaceuticals Co., Ltd. Research Laboratories, Maruzen Pharmaceuticals Co., Ltd. To improve the taste profile of glycyrrhizin (1, the saponin of licorice root, relative sweetness to sucrose : x 170), a variety of 3-O-glycosides of glycyrrhetic acid were prepared and their sweetness evaluated. It was found that a signiticant enhancement of sweetness was observed for the 3-O-β-D-xyloside and the 3-O-β-D-glucuronide (MGGR). Especially, MGGR had a high sweetness relative to sucrose ; x941, and would appear to be a new potent sweetener.