Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin
1994 年 58 巻 9 号 p. 1700-1701
詳細
1994 年 58 巻 9 号 p. 1700-1701
Erbstatin, a tyrosine kinase inhibitor, inhibited p59fyn- and p561ck-kinases in vitro with IC50s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, wasalso inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.
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