Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Suppression of Hydrogen Peroxide-induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Decylubiquinone, a Coenzyme Q Homolog
Tsutomu NakayamaYukie OgisoToshihiko Osawashunro Kawakishi
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1994 年 58 巻 9 号 p. 1702-1704

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The cytotoxicity of hydrogen peroxide (H2O2) toward Chinese hamster V79 cells was assessed with a colony-formation assay. Decylubiquinone, a coenzyme Q homolog, suppressed H2O2-induced cytotoxicity. Almost all the incorporated decylubiquinone was detected as decylubiquinol after incubating the cells for 4h. These results suggest that decylubiquinol reduced in the cells acted as an antioxidant against H2O2-induced oxidative cell injury.

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© Japan Society for Bioscience, Biotechnology, and Agrochemistry
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