Fermentative Production of cis-4-Hydroxy-(L)-proline by Helicocerus oryzae and Acrocylindrium oryzae
1994 年 58 巻 9 号 p. 1747-1748
詳細
1994 年 58 巻 9 号 p. 1747-1748
The production of hydroxyproline by microorganisms was studied to discover the chiral source of the side chain moiety of carbapenem. cis-4-Hydroxy-(L)-proline produced by Helicocerus oryzae and A crocylindrium oryzae was purified from culture broths. The 1NMR spectra and [α]D of purified samples were in agreement with those of standard samples. Our finding provided the first evidence for fermentative production of cis-4-hydroxy-(L)-proline. The addition of (L)-proline to the culture broth of H. oryzae increased the production of cis-4-hydroxy-(L)-proline.
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