Roles of the Dimethylamino Group and Macrodiolide Ring of Pamamycin-607 in Its Aerial Mycelium-inducing Activity

抄録

Four pamamycin-607-degraded products-desdimethylaminopa-mamycin-607, a macrodiolide ring-opened compound, and two constitutent hydroxy acid-were prepared, and their aerial mycelium-inducing activity was measured. The hydroxy acid L part with a dimethylamino group was the principal component responsible for activity. The macrodiolide ring itself was dispensable, but only hydroxy acid L showed very weak activity.