Syntheses of (14β, 15β, 16β, 17α)- and (14β, 15α, 16β, 17α)-1, 3, 5(10)-Estratriene-2, 3, 14, 15, 16, 17-hexaols, Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor, and Their Activity

抄録

Structures are proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and two possible candidates, (14β, 15β, 16β, 17α)- and (14β, 15α, 16α, 17α)-2, 3, 14, 15, 16, 17-hexahydroxy-1, 3, 5(10)-estratrienes, were synthesized. Both compounds were potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.