Inhibitory Effect of Alginic Acids on Hyaluronidase and on Histamine Release from Mast Cells

Masahiro ASADA; Makiko SUGIE; Mami INOUE; Kazuya NAKAGOMI; Seiji HONGO; Katsumi MURATA; Shinji IRIE; Toshio TAKEUCHI; Noboru TOMIZUKA; Syuichi OKA

doi:10.1271/bbb.61.1030

Masahiro ASADA, Makiko SUGIE, Mami INOUE, Kazuya NAKAGOMI, Seiji HONGO, Katsumi MURATA, Shinji IRIE, Toshio TAKEUCHI, Noboru TOMIZUKA, Syuichi OKA

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Keywords: alginic acid, uronic acid, inhibitor, hyaluronidase, mast cell degranulation

JOURNAL FREE ACCESS

1997 Volume 61 Issue 6 Pages 1030-1032

DOI https://doi.org/10.1271/bbb.61.1030

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Abstract

The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell degranulation were examined. Alginic acid with an M/G ratio of 1.0 exhibited the strongest inhibition of both activities, the higher molecular weight alginic acids of 150 to 370kDa being preferable in both cases. Esterification of the carboxyl residue enhanced the latter activity.

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