著者所属：Department of Biosystem Science, Graduate School of Science and Technology, Niigata University Department of Biosystem Science, Graduate School of Science and Technology, Niigata University Department of Chemistry, Faculty of Science, Niigata University Department of Chemistry, Faculty, of Science, Science University of Tokyo
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatived of 1 showed higher toxicity against Salmonella typhimurium TA1537.
