Bioscience and Microflora
Online ISSN : 1349-8355
Print ISSN : 1342-1441
ISSN-L : 1342-1441
Full Paper
Aerobic and Anaerobic Biotransformation of Bile Acids by Escherichia coli (II): No Conversion of α-Muricholic Acid by 7α-Hydroxysteroid Dehydrogenase of E. coli
Yoshio OguraNobuo YamagaTakao SuzukiKoji KimuraYasuhiro KidoKazuo YamadaKiyohisa Uchida
著者情報
ジャーナル フリー

2005 年 24 巻 2 号 p. 41-44

詳細
抄録
The effect of Escherichia coli K-12 on the transformation of hyocholic acid, α-muricholic acid, β-muricholic acid and 3α,7 β,12α-trihydroxy-5β-cholanoic acid was examined in aerobic and anaerobic cultures for 4 days and the activities were compared with those on cholic acid and chenodeoxycholic acid. Hyocholic acid was dehydrogenated, but to a lesser extent than cholic acid or chenodeoxycholic acid. However, α-muricholic acid, which has a 7α-hydroxyl group, was not dehydrogenated even after 4 days. This was confirmed by experiments using a cell-free crude enzyme preparation and by gas chromatographic analysis of bile acids in the medium culture. β-Muricholic acid and 3α,7β,12α-trihydroxy-5 β-cholanoic acid were not changed by Esherichia coli K-12.
著者関連情報
© 2005 by The Japan Bifidus Foundation
前の記事
feedback
Top