抄録
Human-flora-associated (HFA) mice produced by oral inoculation with human fecal suspension to germfree mice were examined on the changes of the composition of fecal flora when they were given high-meat (HM) and high-bran (HB) diet and fructooligosaccharides (FOS). The composition of fecal flora of HFA mice was similar to that of the inoculated human feces. Number of enterobacteriaceae significantly increased with HM diet and decreased with HB diet to the level with basal diet. Bacteroidaceae, clostridia and streptococci decreased their numbers with HB diet, while the number of bifidobacteria in HFA mice fed HB diet was significantly higher than those fed HM or basal diet. The rate of bifidobacteria to total bacteria increased and the numbers of bacteroidaceae and enterobacteriaceae tended to decrease in HFA mice administered FOS solution, but the differences were not statistically significant. These results indicate that the changes of floral composition by different dietary components can be observed more obviously in HFA mice than in humans.
