THE CHOLESTEROL CONTENT OF BLOOD AND TISSUES IN ALLOXAN DIABETES
1954 年 41 巻 4 号 p. 451-456
詳細
1954 年 41 巻 4 号 p. 451-456
The cholesterol content of the blood and the various tissues of alloxan treated rats were estimated at different stages of blood sugar levels.
1. In blood and liver, the total cholesterol increased through all stages of blood sugar levels, whereas the higher ester contents was observed at the initial hyperglycemic and the secondary hypoglycemic stage.
2. The total cholesterol in lung, kidney, heart and spleen showed no significant change. In the heart cholesterol ester decreased, while free cholesterol increased. Such change of ratio was, however, not observed in other organs.
3. Treatment with alloxan reduces rapidly and remarkably the total cholesterol, especialky the esterified, in the adrenal glands.
4. In the stage corresponding to the initial hyperglycemic stage of alloxan rat, a large loss of total cholesterol, especially of the ester form, was found in the adrenals. This fact seems to indicate that there exists an intimate relationship between initial hyperglycemia and an abnormal activity of pituitary-cortical hormones in the case of alloxan rat.
