Syntheses of 2-amino-4-hydroxy-6-hydroxymethylpteridine-10-C¹⁴ and 2-Amino-4-hydroxypteridine-10-C¹⁴ and Their Metabolism in Drosophila melanogaster

抄録

The biosynthesis of sepiapterin by Droso-phila melanogaster (se) was investigated with 2-amino-4-hydroxy-6-hydroxym ethylpteridin e-10-C¹⁴ and reduced 2-amino-4-hydroxypteridine-10-C¹⁴. It was found that after growth with both labelled compounds radioactive isoxan-thopterin and sepiapterin could be isolated by paper chromatography from the adult flies. This evidence show that the hypothesis concerning the biosynthesis of Drosophila-pteridines postulated by us is correct.
The authors wish to thank Professor Kunio Kigoshi for valuable discussions and suggestions.