Histological Analyses of Bacterial Cellulose as a Carrier for BMP-2 in Bone Regeneration in Japanese White Rabbits

抄録

Purpose: Because of its high water capacity and ability to maintain its volume, bacterial cellulose (BC) might be suitable as a sustained-release carrier of BMP-2. This was examined in a rabbit frontal sinus model. Materials and Methods: After moving the bone wall, the sinus membrane was reflected using a mucosal elevator in rabbits. There were three experimental groups: Group A underwent BC grafting only; group B was grafted with BC soaked with BMP-2 (5 μg); and Group C was treated with BMP solution only. Two rabbits in each group were sacrificed at 4 and 8 weeks and tissues sections were stained with hematoxylin-eosin and observed under a light microscope. Result: BC retains its 3D structure histologically. Marked new bone formation was observed along the BC only in group B, treated with BC soaked with BMP-2. Conclusion: The sustained release of BMP-2 from BC has positive effects on bone formation, and it might be developed as a carrier to promote clinical bone formation.