総説
DNAの高次構造スイッチングと遺伝子発現
2002 年 42 巻 4 号 p. 179-184
詳細
2002 年 42 巻 4 号 p. 179-184
Long DNA molecules above the size of several tens kbp undergo marked discrete transition on their higher-order structure. Recent study on single molecular chain observation indicates that the structural transition of DNA induces discrete ON/OFF switching on transcriptional activity. Changes of environmental parameters induce the morphological variation in folded DNA. We propose a hypothesis that appearance of partially unfolded part on chromatin may concern with the promotion of gene expression.
