生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
凝集タンパク質の効率的再生と分光学的フォールディング研究の接点-抗体分子を中心として-
梅津 光央津本 浩平熊谷 泉
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ジャーナル フリー

2004 年 44 巻 3 号 p. 102-107

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Advances in protein engineering, such as phage display technology, enable us to design antibodies. The recombinant proteins can be expressed in various bacterial hosts, but the expression of antibodies in E. coli often makes insoluble particles, which is considered to be attributed to the folding process of immunoglobulin-folded structure. In this article, the folding study of immunoglobulin structure is summarized and the refolding procedure for antibody fragments from inclusion bodies is elucidated on the basis of the physicochemical folding study of immunoglobulin structure.

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© 2004 by THE BIOPHYSICAL SOCIETY OF JAPAN
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