生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
T細胞活性化の時空間的制御機構
横須賀 忠若松 英矢那瀬 紀子秦 喜久美町山 裕亮
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2018 年 58 巻 1 号 p. 005-011

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When T cells recognize their cognate antigens with MHCs on antigen-presenting cells, TCRs are gathering to form a signalosome, so-called a TCR microcluster, which is constructed by kinases and adaptors in their downstream. The other receptors expressing on T cells, such as a set of costimulatory receptors, also form microclusters and possess their own characteristic signals. Various signalosomes on a plasma membrane all together regulate T cell activation in a spatiotemporal fashion.

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© 2018 by THE BIOPHYSICAL SOCIETY OF JAPAN
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