解説
[NiFe]ヒドロゲナーゼがもつ鉄硫黄クラスターによる酸素防御機構
2018 年 58 巻 6 号 p. 297-302
詳細
2018 年 58 巻 6 号 p. 297-302
Hydrogenases play crucial roles in the hydrogen metabolism by catalyzing the simple reaction: H2 ⇄ 2H+ + 2e–. While the enzymes are of industrial importance, there are a number of serious obstacles to the applications such as the catalytic electrode in the fuel cells, which include the stability to O2. Here we summarize the structural and functional properties of [NiFe]-hydrogenases with focusing the protective mechanism against O2. The recent our studies have revealed that not the catalytic site itself but the Fe-S cluster equipped as the electron pathway is of functional importance for preventing from the attack by O2.
