総説
リン脂質フリッパーゼを介するPIEZO1イオンチャネル制御と筋管形態調節
2020 年 60 巻 4 号 p. 222-226
詳細
2020 年 60 巻 4 号 p. 222-226
Fusion of myoblast cells and subsequent formation of multinucleated cells (called myotubes) are fundamental steps for generation of myofibers. In this review we focus on a role of phospholipid flippase complex ATP11A/CDC50A, a phospholipid translocase that transports phospholipids from the outer to the inner leaflets, during myotube formation. We show that translocation of phosphoatidylserine (PS) via phospholipid flippase is essential for positive regulation of PIEZO1, a mechanosensitive ion channel that is activated by membrane tension, thereby promoting RhoA/ROCK-mediated actomyosin formation that is critical for determination of myotube morphology.
