総説
アミロイドの代謝制御と構造多型
キーワード:
amyloid,
protein misfolding,
protein aggregation,
chaperone,
neurodegenerative disease,
amyloid polymorphism
2020 年 60 巻 4 号 p. 236-240
詳細
2020 年 60 巻 4 号 p. 236-240
Propagation of amyloid is achieved by the combination of amyloid formation and disaggregation. Although both processes in the cell are regulated by molecular chaperones such as Hsp104 and Hsp70, the underlying molecular mechanism has remained elusive. Here we review a recent progress of metabolic regulation of amyloid fibrils, and discuss about the effects of dynamic conformational fluctuation of monomeric proteins on structural polymorphism of amyloid. The detailed analysis of the processes of amyloid formation and disaggregation by biophysical methods will provide important mechanistic insights into the cellular process responsible for amyloid propagation.
