2023 年 33 巻 3 号 p. 133-140
In epithelial cell sheets, forces generated by individual cells cause deformation, such as elongation, bending, and twisting, resulting in the formation of three-dimensional organs and tissues. Mechanistically analyzing the deformation behavior from the cellular level to the tissue level is necessary to elucidate the morphogenesis mechanism. In this paper, we discuss a vertex model that mechanistically considers the behavior of individual cells and introduce the possibilities for conducting research using this model.