Peptidoglycan from Bifidobacterium bifidum G9-1 induces IgA secretion in Peyer’s patch-derived cells

Hiroaki KONISHI; Koji YAMAMOTO; Aki SAKATANI; Tatsuya DOKOSHI; Yutaka MAKIZAKI; Yoshiki TANAKA; Hiroshi OHNO; Kentaro MORIICHI; Mikihiro FUJIYA

doi:10.12938/bmfh.2025-040

Note

Peptidoglycan from Bifidobacterium bifidum G9-1 induces IgA secretion in Peyer’s patch-derived cells

Hiroaki KONISHI, Koji YAMAMOTO, Aki SAKATANI, Tatsuya DOKOSHI, Yutaka MAKIZAKI, Yoshiki TANAKA, Hiroshi OHNO, Kentaro MORIICHI, Mikihiro FUJIYA

Author information

Hiroaki KONISHI
Department of Gastroenterology and Advanced Medical Sciences, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Koji YAMAMOTO
Department of Physiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Aki SAKATANI
Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Tatsuya DOKOSHI
Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Yutaka MAKIZAKI
Biofermin Pharmaceutical Co., Ltd., 7-3-4 Higashi-machi, Ibukidai, Nishi-ku, Kobe, Hyogo 651-2242, Japan
Yoshiki TANAKA
Biofermin Pharmaceutical Co., Ltd., 7-3-4 Higashi-machi, Ibukidai, Nishi-ku, Kobe, Hyogo 651-2242, Japan
Hiroshi OHNO
Biofermin Pharmaceutical Co., Ltd., 7-3-4 Higashi-machi, Ibukidai, Nishi-ku, Kobe, Hyogo 651-2242, Japan
Kentaro MORIICHI
Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Mikihiro FUJIYA
Department of Gastroenterology and Advanced Medical Sciences, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan
Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan

Keywords: immunoglobulin A, Bifidobacterium bifidum G9-1, peptidoglycan

JOURNAL OPEN ACCESS

2026 Volume 45 Issue 1 Pages 79-83

DOI https://doi.org/10.12938/bmfh.2025-040

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Abstract

Immunoglobulin A (IgA) plays a key role in mucosal immunity. We investigated the IgA-inducing capacity of heat-killed Bifidobacterium bifidum G9-1 (BBG9-1) using Peyer’s patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Compared with other Gram-positive bacteria, BBG9-1 showed a stronger IgA-inducing effect. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion. These findings suggest that PG from BBG9-1 is a key factor in IgA induction, supporting its potential application in modulating mucosal immune responses.

Corresponding author

Funder information

1.Fund name: Biofermin Pharmaceutical Co., Ltd.

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